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Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations
BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) patients display easy fatigability and abnormal decrements on repetitive nerve stimulation (RNS) test of clinically involved limb muscles, which can result in ALS being misdiagnosed as myasthenia gravis. We retrospectively analyzed the RNS...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Korean Neurological Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079157/ https://www.ncbi.nlm.nih.gov/pubmed/21519524 http://dx.doi.org/10.3988/jcn.2011.7.1.31 |
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author | Kim, Jee Young Park, Kee Duk Kim, Seung-Min Sunwoo, Il Nam |
author_facet | Kim, Jee Young Park, Kee Duk Kim, Seung-Min Sunwoo, Il Nam |
author_sort | Kim, Jee Young |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) patients display easy fatigability and abnormal decrements on repetitive nerve stimulation (RNS) test of clinically involved limb muscles, which can result in ALS being misdiagnosed as myasthenia gravis. We retrospectively analyzed the RNS tests of ten ALS patients with only or predominant oropharyngeal symptoms without ocular or facial weakness. METHODS: RNS tests were performed on the abductor digiti quinti, flexor carpi ulnaris, orbicularis oculi (OO), nasalis and trapezius muscles at low-rate stimulation frequencies of 3 and 5-Hz. Decrements greater than 10% of the compound muscle action potential amplitude on the fifth stimulation compared to the first was regarded as abnormal. RESULTS: Six patients complained of muscular fatigue or diurnal fluctuation. Among the ten patients, three exhibited abnormal decrements during low-rate stimulation in the facial muscles but not in the limb muscles, two exhibited abnormal decrements in the OO and nasalis muscles, and one exhibited abnormal decrements in the OO muscle. CONCLUSIONS: These findings show that the facial muscles may be involved in some early oropharyngeal forms of ALS, although facial weakness may not be clinically evident. We confirm herein that abnormal decrement of facial muscles to RNS test cannot make a definite diagnose for myasthenia gravis. |
format | Text |
id | pubmed-3079157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Neurological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-30791572011-04-25 Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations Kim, Jee Young Park, Kee Duk Kim, Seung-Min Sunwoo, Il Nam J Clin Neurol Original Article BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) patients display easy fatigability and abnormal decrements on repetitive nerve stimulation (RNS) test of clinically involved limb muscles, which can result in ALS being misdiagnosed as myasthenia gravis. We retrospectively analyzed the RNS tests of ten ALS patients with only or predominant oropharyngeal symptoms without ocular or facial weakness. METHODS: RNS tests were performed on the abductor digiti quinti, flexor carpi ulnaris, orbicularis oculi (OO), nasalis and trapezius muscles at low-rate stimulation frequencies of 3 and 5-Hz. Decrements greater than 10% of the compound muscle action potential amplitude on the fifth stimulation compared to the first was regarded as abnormal. RESULTS: Six patients complained of muscular fatigue or diurnal fluctuation. Among the ten patients, three exhibited abnormal decrements during low-rate stimulation in the facial muscles but not in the limb muscles, two exhibited abnormal decrements in the OO and nasalis muscles, and one exhibited abnormal decrements in the OO muscle. CONCLUSIONS: These findings show that the facial muscles may be involved in some early oropharyngeal forms of ALS, although facial weakness may not be clinically evident. We confirm herein that abnormal decrement of facial muscles to RNS test cannot make a definite diagnose for myasthenia gravis. Korean Neurological Association 2011-03 2011-03-31 /pmc/articles/PMC3079157/ /pubmed/21519524 http://dx.doi.org/10.3988/jcn.2011.7.1.31 Text en Copyright © 2011 Korean Neurological Association |
spellingShingle | Original Article Kim, Jee Young Park, Kee Duk Kim, Seung-Min Sunwoo, Il Nam Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations |
title | Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations |
title_full | Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations |
title_fullStr | Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations |
title_full_unstemmed | Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations |
title_short | Repetitive Nerve Stimulation Test in Amyotrophic Lateral Sclerosis with Predominant Oropharyngeal Manifestations |
title_sort | repetitive nerve stimulation test in amyotrophic lateral sclerosis with predominant oropharyngeal manifestations |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079157/ https://www.ncbi.nlm.nih.gov/pubmed/21519524 http://dx.doi.org/10.3988/jcn.2011.7.1.31 |
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