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Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release
Autophagy, a cellular process for organelle and protein turnover, regulates innate immune responses. We demonstrate that depletion of autophagic proteins microtubule associated protein-1 light chain 3B (LC3B) and Beclin 1 enhances caspase-1 activation and secretion of interleukin-1β and interleukin-...
Autores principales: | Nakahira, Kiichi, Haspel, Jeffrey Adam, Rathinam, Vijay AK, Lee, Seon-Jin, Dolinay, Tamas, Lam, Hilaire C, Englert, Joshua A, Rabinovitch, Marlene, Cernadas, Manuela, Kim, Hong Pyo, Fitzgerald, Katherine A, Ryter, Stefan W, Choi, Augustine MK |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079381/ https://www.ncbi.nlm.nih.gov/pubmed/21151103 http://dx.doi.org/10.1038/ni.1980 |
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