Losses of Both Products of the Cdkn2a/Arf Locus Contribute to Asbestos-Induced Mesothelioma Development and Cooperate to Accelerate Tumorigenesis

The CDKN2A/ARF locus encompasses overlapping tumor suppressor genes p16(INK4A) and p14(ARF), which are frequently co-deleted in human malignant mesothelioma (MM). The importance of p16(INK4A) loss in human cancer is well established, but the relative significance of p14(ARF) loss has been debated. T...

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Detalles Bibliográficos
Autores principales: Altomare, Deborah A., Menges, Craig W., Xu, Jinfei, Pei, Jianming, Zhang, Lili, Tadevosyan, Ara, Neumann-Domer, Erin, Liu, Zemin, Carbone, Michele, Chudoba, Ilse, Klein-Szanto, Andres J., Testa, Joseph R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079727/
https://www.ncbi.nlm.nih.gov/pubmed/21526190
http://dx.doi.org/10.1371/journal.pone.0018828

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