A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication and Unfolding/Translocation of the Cholera Toxin A1 Subunit

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality...

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Detalles Bibliográficos
Autores principales: Taylor, Michael, Banerjee, Tuhina, Navarro-Garcia, Fernando, Huerta, Jazmin, Massey, Shane, Burlingame, Mansfield, Pande, Abhay H., Tatulian, Suren A., Teter, Ken
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079739/
https://www.ncbi.nlm.nih.gov/pubmed/21526142
http://dx.doi.org/10.1371/journal.pone.0018825

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