A Cyclic Undecamer Peptide Mimics a Turn in Folded Alzheimer Amyloid β and Elicits Antibodies against Oligomeric and Fibrillar Amyloid and Plaques

The 39- to 42-residue amyloid β (Aβ) peptide is deposited in extracellular fibrillar plaques in the brain of patients suffering from Alzheimer's Disease (AD). Vaccination with these peptides seems to be a promising approach to reduce the plaque load but results in a dominant antibody response d...

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Detalles Bibliográficos
Autores principales: Hoogerhout, Peter, Kamphuis, Willem, Brugghe, Humphrey F., Sluijs, Jacqueline A., Timmermans, Hans A. M., Westdijk, Janny, Zomer, Gijsbert, Boog, Claire J. P., Hol, Elly M., van den Dobbelsteen, Germie P. J. M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079747/
https://www.ncbi.nlm.nih.gov/pubmed/21526148
http://dx.doi.org/10.1371/journal.pone.0019110

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