Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala

This study tested whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Parsons, Ryan G., Davis, Michael
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080103/
https://www.ncbi.nlm.nih.gov/pubmed/21258326
http://dx.doi.org/10.1038/nn.2745
_version_ 1782202077201563648
author Parsons, Ryan G.
Davis, Michael
author_facet Parsons, Ryan G.
Davis, Michael
author_sort Parsons, Ryan G.
collection PubMed
description This study tested whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory.
format Text
id pubmed-3080103
institution National Center for Biotechnology Information
language English
publishDate 2011
record_format MEDLINE/PubMed
spelling pubmed-30801032011-09-01 Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala Parsons, Ryan G. Davis, Michael Nat Neurosci Article This study tested whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory. 2011-01-23 2011-03 /pmc/articles/PMC3080103/ /pubmed/21258326 http://dx.doi.org/10.1038/nn.2745 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Parsons, Ryan G.
Davis, Michael
Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
title Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
title_full Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
title_fullStr Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
title_full_unstemmed Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
title_short Temporary disruption of fear potentiated startle following PKMζ inhibition in the amygdala
title_sort temporary disruption of fear potentiated startle following pkmζ inhibition in the amygdala
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080103/
https://www.ncbi.nlm.nih.gov/pubmed/21258326
http://dx.doi.org/10.1038/nn.2745
work_keys_str_mv AT parsonsryang temporarydisruptionoffearpotentiatedstartlefollowingpkmzinhibitionintheamygdala
AT davismichael temporarydisruptionoffearpotentiatedstartlefollowingpkmzinhibitionintheamygdala

Ejemplares similares