Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front–back polarity in migrating cells

Migratory front–back polarity emerges from the cooperative effect of myosin IIA (MIIA) and IIB (MIIB) on adhesive signaling. We demonstrate here that, during polarization, MIIA and MIIB coordinately promote localized actomyosin bundling, which generates large, stable adhesions that do not signal to...

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Detalles Bibliográficos
Autores principales: Vicente-Manzanares, Miguel, Newell-Litwa, Karen, Bachir, Alexia I., Whitmore, Leanna A., Horwitz, Alan Rick
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080254/
https://www.ncbi.nlm.nih.gov/pubmed/21482721
http://dx.doi.org/10.1083/jcb.201012159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080254/
https://www.ncbi.nlm.nih.gov/pubmed/21482721
http://dx.doi.org/10.1083/jcb.201012159

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