Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

The nonhomologous end-joining (NHEJ) pathway is essential for radioresistance and lymphocyte-specific V(D)J (variable [diversity] joining) recombination. Defects in NHEJ also impair hematopoietic stem cell (HSC) activity with age but do not affect the initial establishment of HSC reserves. In this p...

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Detalles Bibliográficos
Autores principales: Zhang, Shichuan, Yajima, Hirohiko, Huynh, HoangDinh, Zheng, Junke, Callen, Elsa, Chen, Hua-Tang, Wong, Nancy, Bunting, Samuel, Lin, Yu-Fen, Li, Mengxia, Lee, Kyung-Jone, Story, Michael, Gapud, Eric, Sleckman, Barry P., Nussenzweig, André, Zhang, Cheng Cheng, Chen, David J., Chen, Benjamin P.C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080267/
https://www.ncbi.nlm.nih.gov/pubmed/21482716
http://dx.doi.org/10.1083/jcb.201009074

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