Classical Mus musculus Igκ Enhancers Support Transcription but not High Level Somatic Hypermutation from a V-Lambda Promoter in Chicken DT40 Cells

Somatic hypermutation (SHM) of immunoglobulin genes is initiated by activation-induced cytidine deaminase (AID) in activated B cells. This process is strictly dependent on transcription. Hence, cis-acting transcriptional control elements have been proposed to target SHM to immunoglobulin loci. The M...

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Detalles Bibliográficos
Autores principales: Kothapalli, Naga Rama, Norton, Darrell D., Fugmann, Sebastian D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080390/
https://www.ncbi.nlm.nih.gov/pubmed/21533098
http://dx.doi.org/10.1371/journal.pone.0018955

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