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Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus

BACKGROUND: We examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM). METHODS: A 75-g oral glucose tolerance test (OGTT) was c...

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Autores principales: Yu, Sung Hoon, Cho, Bongjun, Lee, Yejin, Kim, Eunhye, Choi, Sung Hee, Lim, Soo, Yi, Ka Hee, Park, Young Joo, Park, Kyong Soo, Jang, Hak Chul
Formato: Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080573/
https://www.ncbi.nlm.nih.gov/pubmed/21537414
http://dx.doi.org/10.4093/dmj.2011.35.1.58
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author Yu, Sung Hoon
Cho, Bongjun
Lee, Yejin
Kim, Eunhye
Choi, Sung Hee
Lim, Soo
Yi, Ka Hee
Park, Young Joo
Park, Kyong Soo
Jang, Hak Chul
author_facet Yu, Sung Hoon
Cho, Bongjun
Lee, Yejin
Kim, Eunhye
Choi, Sung Hee
Lim, Soo
Yi, Ka Hee
Park, Young Joo
Park, Kyong Soo
Jang, Hak Chul
author_sort Yu, Sung Hoon
collection PubMed
description BACKGROUND: We examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM). METHODS: A 75-g oral glucose tolerance test (OGTT) was conducted on 34 women with pGDM. In addition, 11 women with normal glucose tolerance, matched for age, height and weight, were also tested. The insulin, GIP, GLP-1, and glucagon concentrations were measured, and their anthropometric and biochemical markers were also measured. RESULTS: Among 34 women with pGDM, 18 had normal glucose tolerance, 13 had impaired glucose tolerance (IGT) and 1 had diabetes. No significant differences were found in GLP-1 concentration between the pGDM and control group. However, a significantly high level of glucagon was present in the pGDM group at 30 minutes into the OGTT. The GIP concentration was elevated at 30 minutes and 60 minutes in the pGDM group. With the exception of the 30-minute timepoint, women with IGT had significantly high blood glucose from 0 to 120 minutes. However, there was no significant difference in insulin or GLP-1 concentration. The GIP level was significantly high from 0 to 90 minutes in patients diagnosed with IGT. CONCLUSION: GLP-1 secretion does not differ between pGDM patients and normal women. GIP was elevated, but that does not seem to induce in increase in insulin secretion. Therefore, we conclude that other factors such as heredity and environment play important roles in the development of type 2 diabetes.
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spelling pubmed-30805732011-05-02 Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus Yu, Sung Hoon Cho, Bongjun Lee, Yejin Kim, Eunhye Choi, Sung Hee Lim, Soo Yi, Ka Hee Park, Young Joo Park, Kyong Soo Jang, Hak Chul Diabetes Metab J Original Article BACKGROUND: We examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM). METHODS: A 75-g oral glucose tolerance test (OGTT) was conducted on 34 women with pGDM. In addition, 11 women with normal glucose tolerance, matched for age, height and weight, were also tested. The insulin, GIP, GLP-1, and glucagon concentrations were measured, and their anthropometric and biochemical markers were also measured. RESULTS: Among 34 women with pGDM, 18 had normal glucose tolerance, 13 had impaired glucose tolerance (IGT) and 1 had diabetes. No significant differences were found in GLP-1 concentration between the pGDM and control group. However, a significantly high level of glucagon was present in the pGDM group at 30 minutes into the OGTT. The GIP concentration was elevated at 30 minutes and 60 minutes in the pGDM group. With the exception of the 30-minute timepoint, women with IGT had significantly high blood glucose from 0 to 120 minutes. However, there was no significant difference in insulin or GLP-1 concentration. The GIP level was significantly high from 0 to 90 minutes in patients diagnosed with IGT. CONCLUSION: GLP-1 secretion does not differ between pGDM patients and normal women. GIP was elevated, but that does not seem to induce in increase in insulin secretion. Therefore, we conclude that other factors such as heredity and environment play important roles in the development of type 2 diabetes. Korean Diabetes Association 2011-02 2011-02-28 /pmc/articles/PMC3080573/ /pubmed/21537414 http://dx.doi.org/10.4093/dmj.2011.35.1.58 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Yu, Sung Hoon
Cho, Bongjun
Lee, Yejin
Kim, Eunhye
Choi, Sung Hee
Lim, Soo
Yi, Ka Hee
Park, Young Joo
Park, Kyong Soo
Jang, Hak Chul
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
title Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
title_full Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
title_fullStr Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
title_full_unstemmed Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
title_short Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
title_sort insulin secretion and incretin hormone concentration in women with previous gestational diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080573/
https://www.ncbi.nlm.nih.gov/pubmed/21537414
http://dx.doi.org/10.4093/dmj.2011.35.1.58
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