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Gene Expression Profiling in Rodent Models for Schizophrenia

The complex neurodevelopmental disorder schizophrenia is thought to be induced by an interaction between predisposing genes and environmental stressors. In order to get a better insight into the aetiology of this complex disorder, animal models have been developed. In this review, we summarize mRNA...

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Detalles Bibliográficos
Autores principales: Schijndel, Jessica E. Van, Martens, Gerard J.M
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080594/
https://www.ncbi.nlm.nih.gov/pubmed/21629445
http://dx.doi.org/10.2174/157015910793358132
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author Schijndel, Jessica E. Van
Martens, Gerard J.M
author_facet Schijndel, Jessica E. Van
Martens, Gerard J.M
author_sort Schijndel, Jessica E. Van
collection PubMed
description The complex neurodevelopmental disorder schizophrenia is thought to be induced by an interaction between predisposing genes and environmental stressors. In order to get a better insight into the aetiology of this complex disorder, animal models have been developed. In this review, we summarize mRNA expression profiling studies on neurodevelopmental, pharmacological and genetic animal models for schizophrenia. We discuss parallels and contradictions among these studies, and propose strategies for future research.
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spelling pubmed-30805942011-06-01 Gene Expression Profiling in Rodent Models for Schizophrenia Schijndel, Jessica E. Van Martens, Gerard J.M Curr Neuropharmacol Article The complex neurodevelopmental disorder schizophrenia is thought to be induced by an interaction between predisposing genes and environmental stressors. In order to get a better insight into the aetiology of this complex disorder, animal models have been developed. In this review, we summarize mRNA expression profiling studies on neurodevelopmental, pharmacological and genetic animal models for schizophrenia. We discuss parallels and contradictions among these studies, and propose strategies for future research. Bentham Science Publishers Ltd 2010-12 /pmc/articles/PMC3080594/ /pubmed/21629445 http://dx.doi.org/10.2174/157015910793358132 Text en ©2010 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Schijndel, Jessica E. Van
Martens, Gerard J.M
Gene Expression Profiling in Rodent Models for Schizophrenia
title Gene Expression Profiling in Rodent Models for Schizophrenia
title_full Gene Expression Profiling in Rodent Models for Schizophrenia
title_fullStr Gene Expression Profiling in Rodent Models for Schizophrenia
title_full_unstemmed Gene Expression Profiling in Rodent Models for Schizophrenia
title_short Gene Expression Profiling in Rodent Models for Schizophrenia
title_sort gene expression profiling in rodent models for schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080594/
https://www.ncbi.nlm.nih.gov/pubmed/21629445
http://dx.doi.org/10.2174/157015910793358132
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