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An Update on GABAρ Receptors
The present review discusses the functional and molecular diversity of GABAρ receptors. These receptors were originally described in the mammalian retina, and their functional role in the visual pathway has been recently elucidated; however new studies on their distribution in the brain and spinal c...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Bentham Science Publishers Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080597/ https://www.ncbi.nlm.nih.gov/pubmed/21629448 http://dx.doi.org/10.2174/157015910793358141 |
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author | Martínez-Delgado, Gustavo Estrada-Mondragón, Argel Miledi, Ricardo Martínez-Torres, Ataúlfo |
author_facet | Martínez-Delgado, Gustavo Estrada-Mondragón, Argel Miledi, Ricardo Martínez-Torres, Ataúlfo |
author_sort | Martínez-Delgado, Gustavo |
collection | PubMed |
description | The present review discusses the functional and molecular diversity of GABAρ receptors. These receptors were originally described in the mammalian retina, and their functional role in the visual pathway has been recently elucidated; however new studies on their distribution in the brain and spinal cord have revealed that they are more spread than originally thought, and thus it will be important to determine their physiological contribution to the GABAergic transmission in other areas of the central nervous system. In addition, molecular modeling has revealed peculiar traits of these receptors that have impacted on the interpretations of the latest pharmacolgical and biophysical findings. Finally, sequencing of several vertebrate genomes has permitted a comparative analysis of the organization of the GABAρ genes. |
format | Text |
id | pubmed-3080597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Bentham Science Publishers Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-30805972011-06-01 An Update on GABAρ Receptors Martínez-Delgado, Gustavo Estrada-Mondragón, Argel Miledi, Ricardo Martínez-Torres, Ataúlfo Curr Neuropharmacol Article The present review discusses the functional and molecular diversity of GABAρ receptors. These receptors were originally described in the mammalian retina, and their functional role in the visual pathway has been recently elucidated; however new studies on their distribution in the brain and spinal cord have revealed that they are more spread than originally thought, and thus it will be important to determine their physiological contribution to the GABAergic transmission in other areas of the central nervous system. In addition, molecular modeling has revealed peculiar traits of these receptors that have impacted on the interpretations of the latest pharmacolgical and biophysical findings. Finally, sequencing of several vertebrate genomes has permitted a comparative analysis of the organization of the GABAρ genes. Bentham Science Publishers Ltd 2010-12 /pmc/articles/PMC3080597/ /pubmed/21629448 http://dx.doi.org/10.2174/157015910793358141 Text en ©2010 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by-nc/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Martínez-Delgado, Gustavo Estrada-Mondragón, Argel Miledi, Ricardo Martínez-Torres, Ataúlfo An Update on GABAρ Receptors |
title | An Update on GABAρ Receptors |
title_full | An Update on GABAρ Receptors |
title_fullStr | An Update on GABAρ Receptors |
title_full_unstemmed | An Update on GABAρ Receptors |
title_short | An Update on GABAρ Receptors |
title_sort | update on gabaρ receptors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080597/ https://www.ncbi.nlm.nih.gov/pubmed/21629448 http://dx.doi.org/10.2174/157015910793358141 |
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