A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis

We describe a 72-year-old man, who had been suffered from Henoch-Schönlein purpura (HSP) several times, presented with hematoproteinuria with granular cast, and general lymphadenopathy. The immunological examination of the serum showed polyclonal hypergammagloburinemia with high value of IgG4. The r...

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Autores principales: Tamai, Rukako, Hasegawa, Yoshiyuki, Hisano, Satoshi, Miyake, Katsuhisa, Nakashima, Hitoshi, Saito, Takao
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080809/
https://www.ncbi.nlm.nih.gov/pubmed/21450108
http://dx.doi.org/10.1186/1710-1492-7-5
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author Tamai, Rukako
Hasegawa, Yoshiyuki
Hisano, Satoshi
Miyake, Katsuhisa
Nakashima, Hitoshi
Saito, Takao
author_facet Tamai, Rukako
Hasegawa, Yoshiyuki
Hisano, Satoshi
Miyake, Katsuhisa
Nakashima, Hitoshi
Saito, Takao
author_sort Tamai, Rukako
collection PubMed
description We describe a 72-year-old man, who had been suffered from Henoch-Schönlein purpura (HSP) several times, presented with hematoproteinuria with granular cast, and general lymphadenopathy. The immunological examination of the serum showed polyclonal hypergammagloburinemia with high value of IgG4. The renal biopsy revealed interstitial inflammatory cell infiltration, including infiltration of lymphocytes and plasma cells, and segmental glomerulonephritis. Direct immunofluorescence microscopy revealed apparent positive staining with anti-human IgA, and anti-human IgG in glomeruli, anti-human IgG4 antibody staining showed many positive plasma cells in the interstitium. The patient was diagnosed with HSP nephritis that was complicated by IgG4-related nephropathy. As a result of the treatment with 30mg prednisolone, the swelling of the LNs decreased, but the patient continued to have persistent hematoproteinuria.
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spelling pubmed-30808092011-04-22 A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis Tamai, Rukako Hasegawa, Yoshiyuki Hisano, Satoshi Miyake, Katsuhisa Nakashima, Hitoshi Saito, Takao Allergy Asthma Clin Immunol Case Report We describe a 72-year-old man, who had been suffered from Henoch-Schönlein purpura (HSP) several times, presented with hematoproteinuria with granular cast, and general lymphadenopathy. The immunological examination of the serum showed polyclonal hypergammagloburinemia with high value of IgG4. The renal biopsy revealed interstitial inflammatory cell infiltration, including infiltration of lymphocytes and plasma cells, and segmental glomerulonephritis. Direct immunofluorescence microscopy revealed apparent positive staining with anti-human IgA, and anti-human IgG in glomeruli, anti-human IgG4 antibody staining showed many positive plasma cells in the interstitium. The patient was diagnosed with HSP nephritis that was complicated by IgG4-related nephropathy. As a result of the treatment with 30mg prednisolone, the swelling of the LNs decreased, but the patient continued to have persistent hematoproteinuria. BioMed Central 2011-03-31 /pmc/articles/PMC3080809/ /pubmed/21450108 http://dx.doi.org/10.1186/1710-1492-7-5 Text en Copyright ©2011 Tamai et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tamai, Rukako
Hasegawa, Yoshiyuki
Hisano, Satoshi
Miyake, Katsuhisa
Nakashima, Hitoshi
Saito, Takao
A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis
title A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis
title_full A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis
title_fullStr A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis
title_full_unstemmed A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis
title_short A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis
title_sort case of igg4-related tubulointerstitial nephritis concurrent with henoch-schönlein purpura nephritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080809/
https://www.ncbi.nlm.nih.gov/pubmed/21450108
http://dx.doi.org/10.1186/1710-1492-7-5
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