Cargando…
The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in China
BACKGROUND: Mainland China experienced pandemic influenza H1N1 (2009) virus (pH1N1) with peak activity during November-December 2009. To understand the geographic extent, risk factors, and attack rate of pH1N1 infection in China we conducted a nationwide serological survey to determine the prevalenc...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080876/ https://www.ncbi.nlm.nih.gov/pubmed/21533034 http://dx.doi.org/10.1371/journal.pone.0017919 |
_version_ | 1782202158006927360 |
---|---|
author | Xu, Cuiling Bai, Tian Iuliano, A. Danielle Wang, Min Yang, Lei Wen, Leying Zeng, Yuhong Li, Xiaodan Chen, Tao Wang, Wei Hu, Ying Yang, Limei Li, Zi Zou, Shumei Li, Dexin Wang, Shiwen Feng, Zijian Zhang, Yanping Yu, Hongjie Yang, Weizhong Wang, Yu Widdowson, Marc-Alain Shu, Yuelong |
author_facet | Xu, Cuiling Bai, Tian Iuliano, A. Danielle Wang, Min Yang, Lei Wen, Leying Zeng, Yuhong Li, Xiaodan Chen, Tao Wang, Wei Hu, Ying Yang, Limei Li, Zi Zou, Shumei Li, Dexin Wang, Shiwen Feng, Zijian Zhang, Yanping Yu, Hongjie Yang, Weizhong Wang, Yu Widdowson, Marc-Alain Shu, Yuelong |
author_sort | Xu, Cuiling |
collection | PubMed |
description | BACKGROUND: Mainland China experienced pandemic influenza H1N1 (2009) virus (pH1N1) with peak activity during November-December 2009. To understand the geographic extent, risk factors, and attack rate of pH1N1 infection in China we conducted a nationwide serological survey to determine the prevalence of antibodies to pH1N1. METHODOLOGY/PRINCIPAL FINDINGS: Stored serum samples (n = 2,379) collected during 2006-2008 were used to estimate baseline serum reactogenicity to pH1N1. In January 2010, we used a multistage-stratified random sampling method to select 50,111 subjects who met eligibility criteria and collected serum samples and administered a standardized questionnaire. Antibody response to pH1N1 was measured using haemagglutination inhibition (HI) assay and the weighted seroprevalence was calculated using the Taylor series linearization method. Multivariable logistic regression analyses were used to examine risk factors for pH1N1 seropositivity. Baseline seroprevalence of pH1N1 antibody (HI titer ≥40) was 1.2%. The weighted seroprevalence of pH1N1 among the Chinese population was 21.5%(vaccinated: 62.0%; unvaccinated: 17.1%). Among unvaccinated participants, those aged 6-15 years (32.9%) and 16-24 years (30.3%) had higher seroprevalence compared with participants aged 25–59 years (10.7%) and ≥60 years (9.9%, P<0.0001). Children in kindergarten and students had higher odds of seropositivity than children in family care (OR: 1.36 and 2.05, respectively). We estimated that 207.7 million individuals (15.9%) experienced pH1N1 infection in China. CONCLUSIONS/SIGNIFICANCE: The Chinese population had low pre-existing immunity to pH1N1 and experienced a relatively high attack rate in 2009 of this virus. We recommend routine control measures such as vaccination to reduce transmission and spread of seasonal and pandemic influenza viruses. |
format | Text |
id | pubmed-3080876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30808762011-04-29 The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in China Xu, Cuiling Bai, Tian Iuliano, A. Danielle Wang, Min Yang, Lei Wen, Leying Zeng, Yuhong Li, Xiaodan Chen, Tao Wang, Wei Hu, Ying Yang, Limei Li, Zi Zou, Shumei Li, Dexin Wang, Shiwen Feng, Zijian Zhang, Yanping Yu, Hongjie Yang, Weizhong Wang, Yu Widdowson, Marc-Alain Shu, Yuelong PLoS One Research Article BACKGROUND: Mainland China experienced pandemic influenza H1N1 (2009) virus (pH1N1) with peak activity during November-December 2009. To understand the geographic extent, risk factors, and attack rate of pH1N1 infection in China we conducted a nationwide serological survey to determine the prevalence of antibodies to pH1N1. METHODOLOGY/PRINCIPAL FINDINGS: Stored serum samples (n = 2,379) collected during 2006-2008 were used to estimate baseline serum reactogenicity to pH1N1. In January 2010, we used a multistage-stratified random sampling method to select 50,111 subjects who met eligibility criteria and collected serum samples and administered a standardized questionnaire. Antibody response to pH1N1 was measured using haemagglutination inhibition (HI) assay and the weighted seroprevalence was calculated using the Taylor series linearization method. Multivariable logistic regression analyses were used to examine risk factors for pH1N1 seropositivity. Baseline seroprevalence of pH1N1 antibody (HI titer ≥40) was 1.2%. The weighted seroprevalence of pH1N1 among the Chinese population was 21.5%(vaccinated: 62.0%; unvaccinated: 17.1%). Among unvaccinated participants, those aged 6-15 years (32.9%) and 16-24 years (30.3%) had higher seroprevalence compared with participants aged 25–59 years (10.7%) and ≥60 years (9.9%, P<0.0001). Children in kindergarten and students had higher odds of seropositivity than children in family care (OR: 1.36 and 2.05, respectively). We estimated that 207.7 million individuals (15.9%) experienced pH1N1 infection in China. CONCLUSIONS/SIGNIFICANCE: The Chinese population had low pre-existing immunity to pH1N1 and experienced a relatively high attack rate in 2009 of this virus. We recommend routine control measures such as vaccination to reduce transmission and spread of seasonal and pandemic influenza viruses. Public Library of Science 2011-04-21 /pmc/articles/PMC3080876/ /pubmed/21533034 http://dx.doi.org/10.1371/journal.pone.0017919 Text en Xu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Xu, Cuiling Bai, Tian Iuliano, A. Danielle Wang, Min Yang, Lei Wen, Leying Zeng, Yuhong Li, Xiaodan Chen, Tao Wang, Wei Hu, Ying Yang, Limei Li, Zi Zou, Shumei Li, Dexin Wang, Shiwen Feng, Zijian Zhang, Yanping Yu, Hongjie Yang, Weizhong Wang, Yu Widdowson, Marc-Alain Shu, Yuelong The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in China |
title | The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in
China |
title_full | The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in
China |
title_fullStr | The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in
China |
title_full_unstemmed | The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in
China |
title_short | The Seroprevalence of Pandemic Influenza H1N1 (2009) Virus in
China |
title_sort | seroprevalence of pandemic influenza h1n1 (2009) virus in
china |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080876/ https://www.ncbi.nlm.nih.gov/pubmed/21533034 http://dx.doi.org/10.1371/journal.pone.0017919 |
work_keys_str_mv | AT xucuiling theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT baitian theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT iulianoadanielle theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangmin theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT yanglei theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT wenleying theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT zengyuhong theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT lixiaodan theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT chentao theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangwei theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT huying theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT yanglimei theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT lizi theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT zoushumei theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT lidexin theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangshiwen theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT fengzijian theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT zhangyanping theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT yuhongjie theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT yangweizhong theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangyu theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT widdowsonmarcalain theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT shuyuelong theseroprevalenceofpandemicinfluenzah1n12009virusinchina AT xucuiling seroprevalenceofpandemicinfluenzah1n12009virusinchina AT baitian seroprevalenceofpandemicinfluenzah1n12009virusinchina AT iulianoadanielle seroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangmin seroprevalenceofpandemicinfluenzah1n12009virusinchina AT yanglei seroprevalenceofpandemicinfluenzah1n12009virusinchina AT wenleying seroprevalenceofpandemicinfluenzah1n12009virusinchina AT zengyuhong seroprevalenceofpandemicinfluenzah1n12009virusinchina AT lixiaodan seroprevalenceofpandemicinfluenzah1n12009virusinchina AT chentao seroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangwei seroprevalenceofpandemicinfluenzah1n12009virusinchina AT huying seroprevalenceofpandemicinfluenzah1n12009virusinchina AT yanglimei seroprevalenceofpandemicinfluenzah1n12009virusinchina AT lizi seroprevalenceofpandemicinfluenzah1n12009virusinchina AT zoushumei seroprevalenceofpandemicinfluenzah1n12009virusinchina AT lidexin seroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangshiwen seroprevalenceofpandemicinfluenzah1n12009virusinchina AT fengzijian seroprevalenceofpandemicinfluenzah1n12009virusinchina AT zhangyanping seroprevalenceofpandemicinfluenzah1n12009virusinchina AT yuhongjie seroprevalenceofpandemicinfluenzah1n12009virusinchina AT yangweizhong seroprevalenceofpandemicinfluenzah1n12009virusinchina AT wangyu seroprevalenceofpandemicinfluenzah1n12009virusinchina AT widdowsonmarcalain seroprevalenceofpandemicinfluenzah1n12009virusinchina AT shuyuelong seroprevalenceofpandemicinfluenzah1n12009virusinchina |