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Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function

BACKGROUND: Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. OBJECTIVES: We examined the association between medium-term concentrations of black carbon (BC) estimated by land-use regres...

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Autores principales: Alexeeff, Stacey E., Coull, Brent A., Gryparis, Alexandros, Suh, Helen, Sparrow, David, Vokonas, Pantel S., Schwartz, Joel
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080929/
https://www.ncbi.nlm.nih.gov/pubmed/21349799
http://dx.doi.org/10.1289/ehp.1002560
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author Alexeeff, Stacey E.
Coull, Brent A.
Gryparis, Alexandros
Suh, Helen
Sparrow, David
Vokonas, Pantel S.
Schwartz, Joel
author_facet Alexeeff, Stacey E.
Coull, Brent A.
Gryparis, Alexandros
Suh, Helen
Sparrow, David
Vokonas, Pantel S.
Schwartz, Joel
author_sort Alexeeff, Stacey E.
collection PubMed
description BACKGROUND: Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. OBJECTIVES: We examined the association between medium-term concentrations of black carbon (BC) estimated by land-use regression and levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), both markers of inflammatory and endothelial response. METHODS: We studied 642 elderly men participating in the Veterans Administration (VA) Normative Aging Study with repeated measurements of sICAM-1 and sVCAM-1 during 1999–2008. Daily estimates of BC exposure at each geocoded participant address were derived using a validated spatiotemporal model and averaged to form 4-, 8-, and 12-week exposures. We used linear mixed models to estimate associations, controlling for confounders. We examined effect modification by statin use, obesity, and diabetes. RESULTS: We found statistically significant positive associations between BC and sICAM-1 for averages of 4, 8, and 12 weeks. An interquartile-range increase in 8-week BC exposure (0.30 μg/m(3)) was associated with a 1.58% increase in sICAM-1 (95% confidence interval, 0.18–3.00%). Overall associations between sVCAM-1 and BC exposures were suggestive but not statistically significant. We found a significant interaction with diabetes—where diabetics were more susceptible to the effect of BC—for both sICAM-1 and sVCAM-1. We also observed an interaction with statin use, which was statistically significant for sVCAM-1 and suggestive for sICAM-1. We found no evidence of an interaction with obesity. CONCLUSION: Our results suggest that medium-term exposure to TRAP may induce an increased inflammatory/endothelial response, especially among diabetics and those not using statins.
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spelling pubmed-30809292011-05-03 Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function Alexeeff, Stacey E. Coull, Brent A. Gryparis, Alexandros Suh, Helen Sparrow, David Vokonas, Pantel S. Schwartz, Joel Environ Health Perspect Research BACKGROUND: Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP. OBJECTIVES: We examined the association between medium-term concentrations of black carbon (BC) estimated by land-use regression and levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1), both markers of inflammatory and endothelial response. METHODS: We studied 642 elderly men participating in the Veterans Administration (VA) Normative Aging Study with repeated measurements of sICAM-1 and sVCAM-1 during 1999–2008. Daily estimates of BC exposure at each geocoded participant address were derived using a validated spatiotemporal model and averaged to form 4-, 8-, and 12-week exposures. We used linear mixed models to estimate associations, controlling for confounders. We examined effect modification by statin use, obesity, and diabetes. RESULTS: We found statistically significant positive associations between BC and sICAM-1 for averages of 4, 8, and 12 weeks. An interquartile-range increase in 8-week BC exposure (0.30 μg/m(3)) was associated with a 1.58% increase in sICAM-1 (95% confidence interval, 0.18–3.00%). Overall associations between sVCAM-1 and BC exposures were suggestive but not statistically significant. We found a significant interaction with diabetes—where diabetics were more susceptible to the effect of BC—for both sICAM-1 and sVCAM-1. We also observed an interaction with statin use, which was statistically significant for sVCAM-1 and suggestive for sICAM-1. We found no evidence of an interaction with obesity. CONCLUSION: Our results suggest that medium-term exposure to TRAP may induce an increased inflammatory/endothelial response, especially among diabetics and those not using statins. National Institute of Environmental Health Sciences 2011-04 2011-02-24 /pmc/articles/PMC3080929/ /pubmed/21349799 http://dx.doi.org/10.1289/ehp.1002560 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Alexeeff, Stacey E.
Coull, Brent A.
Gryparis, Alexandros
Suh, Helen
Sparrow, David
Vokonas, Pantel S.
Schwartz, Joel
Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
title Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
title_full Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
title_fullStr Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
title_full_unstemmed Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
title_short Medium-Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial Function
title_sort medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080929/
https://www.ncbi.nlm.nih.gov/pubmed/21349799
http://dx.doi.org/10.1289/ehp.1002560
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