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Para- and Ortho-Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity

BACKGROUND: Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+)) signaling; however, specific mechanisms have yet to be defined. OBJECTIVE: We aimed to define the structure–acti...

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Detalles Bibliográficos
Autores principales:	Kim, Kyung Ho, Bose, Diptiman D., Ghogha, Atefeh, Riehl, Joyce, Zhang, Rui, Barnhart, Christopher D., Lein, Pamela J., Pessah, Isaac N.
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080935/ https://www.ncbi.nlm.nih.gov/pubmed/21106467 http://dx.doi.org/10.1289/ehp.1002728

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