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Development of an online SPE–LC–MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors

Soluble epoxide hydrolase (sEH) is a promising therapeutic target for the treatment of hypertension, pain, and inflammation-related diseases. In order to enable the development of sEH inhibitors (sEHIs), assays are needed for determination of their potency. Therefore, we developed a new method utili...

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Detalles Bibliográficos
Autores principales:	Schebb, Nils Helge, Huby, Marion, Morisseau, Christophe, Hwang, Sung Hee, Hammock, Bruce D.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2011
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081056/ https://www.ncbi.nlm.nih.gov/pubmed/21479549 http://dx.doi.org/10.1007/s00216-011-4861-2

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