Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy

BACKGROUND: IgE-mediated peanut allergy is a complex trait with strong heritability, but its genetic basis is currently unknown. Loss-of-function mutations within the filaggrin gene are associated with atopic dermatitis and other atopic diseases; therefore, filaggrin is a candidate gene in the etiol...

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Detalles Bibliográficos
Autores principales: Brown, Sara J., Asai, Yuka, Cordell, Heather J., Campbell, Linda E., Zhao, Yiwei, Liao, Haihui, Northstone, Kate, Henderson, John, Alizadehfar, Reza, Ben-Shoshan, Moshe, Morgan, Kenneth, Roberts, Graham, Masthoff, Laury J.N., Pasmans, Suzanne G.M.A., van den Akker, Peter C., Wijmenga, Cisca, Hourihane, Jonathan O’B., Palmer, Colin N.A., Lack, Gideon, Clarke, Ann, Hull, Peter R., Irvine, Alan D., McLean, W. H. Irwin
Formato: Texto
Lenguaje:English
Publicado: Mosby 2011
Materias:
Special section: Food allergy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081065/
https://www.ncbi.nlm.nih.gov/pubmed/21377035
http://dx.doi.org/10.1016/j.jaci.2011.01.031

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