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Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1

We recently identified human P-selectin glycoprotein ligand-1 (PSGL-1) as a functional enterovirus 71 (EV71) receptor and demonstrated PSGL-1-dependent replication for some EV71 strains in human leukocytes. Here, we report that four out of five PSGL-1-binding strains of EV71 replicated poorly in mou...

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Detalles Bibliográficos
Autores principales: Miyamura, Kohei, Nishimura, Yorihiro, Abo, Masahiro, Wakita, Takaji, Shimizu, Hiroyuki
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081077/
https://www.ncbi.nlm.nih.gov/pubmed/20943886
http://dx.doi.org/10.1099/vir.0.022418-0