Matriptase initiates epidermal prokallikrein activation and disease onset in a mouse model of Netherton syndrome

Deficiency in the serine protease inhibitor LEKTI is the etiological origin of Netherton syndrome. The principal morbidities of the disease are stratum corneum detachment and chronic inflammation. We show that the membrane protease, matriptase, initiates Netherton syndrome in a LEKTI-deficient mouse...

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Detalles Bibliográficos
Autores principales: Sales, Katiuchia Uzzun, Masedunskas, Andrius, Bey, Alexandra L., Rasmussen, Amber, Weigert, Roberto, List, Karin, Szabo, Roman, Overbeek, Paul A., Bugge, Thomas H.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081165/
https://www.ncbi.nlm.nih.gov/pubmed/20657595
http://dx.doi.org/10.1038/ng.629

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