CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease

It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells are known. Here we show that CD94, a molecule preferentially expressed by NK cells, is essential for th...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Min, Orr, Mark T., Spee, Pieter, Egebjerg, Thomas, Lanier, Lewis L., Sigal, Luis J.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081423/
https://www.ncbi.nlm.nih.gov/pubmed/21439856
http://dx.doi.org/10.1016/j.immuni.2011.02.015
_version_ 1782202209787707392
author Fang, Min
Orr, Mark T.
Spee, Pieter
Egebjerg, Thomas
Lanier, Lewis L.
Sigal, Luis J.
author_facet Fang, Min
Orr, Mark T.
Spee, Pieter
Egebjerg, Thomas
Lanier, Lewis L.
Sigal, Luis J.
author_sort Fang, Min
collection PubMed
description It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells are known. Here we show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus. Ectromelia virus-infected cells expressing the major histocompatibility complex (MHC) class Ib molecule Qa-1(b) are specifically recognized by the activating receptor formed by CD94 and NKG2E. Because CD94-NKG2 receptors and their ligands are highly conserved in rodents and humans, a similar mechanism may exist during human infections with the smallpox and monkeypox viruses, which are highly homologous to ectromelia virus.
format Text
id pubmed-3081423
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-30814232012-04-22 CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease Fang, Min Orr, Mark T. Spee, Pieter Egebjerg, Thomas Lanier, Lewis L. Sigal, Luis J. Immunity Article It is well established that natural killer (NK) cells confer resistance to many viral diseases, but in only a few instances the molecular mechanisms whereby NK cells recognize virus-infected cells are known. Here we show that CD94, a molecule preferentially expressed by NK cells, is essential for the resistance of C57BL/6 mice to mousepox, a disease caused by the Orthopoxvirus ectromelia virus. Ectromelia virus-infected cells expressing the major histocompatibility complex (MHC) class Ib molecule Qa-1(b) are specifically recognized by the activating receptor formed by CD94 and NKG2E. Because CD94-NKG2 receptors and their ligands are highly conserved in rodents and humans, a similar mechanism may exist during human infections with the smallpox and monkeypox viruses, which are highly homologous to ectromelia virus. Elsevier Inc. 2011-04-22 2011-03-24 /pmc/articles/PMC3081423/ /pubmed/21439856 http://dx.doi.org/10.1016/j.immuni.2011.02.015 Text en Copyright © 2011 Elsevier Inc. All rights reserved. Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.
spellingShingle Article
Fang, Min
Orr, Mark T.
Spee, Pieter
Egebjerg, Thomas
Lanier, Lewis L.
Sigal, Luis J.
CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
title CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
title_full CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
title_fullStr CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
title_full_unstemmed CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
title_short CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
title_sort cd94 is essential for nk cell-mediated resistance to a lethal viral disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081423/
https://www.ncbi.nlm.nih.gov/pubmed/21439856
http://dx.doi.org/10.1016/j.immuni.2011.02.015
work_keys_str_mv AT fangmin cd94isessentialfornkcellmediatedresistancetoalethalviraldisease
AT orrmarkt cd94isessentialfornkcellmediatedresistancetoalethalviraldisease
AT speepieter cd94isessentialfornkcellmediatedresistancetoalethalviraldisease
AT egebjergthomas cd94isessentialfornkcellmediatedresistancetoalethalviraldisease
AT lanierlewisl cd94isessentialfornkcellmediatedresistancetoalethalviraldisease
AT sigalluisj cd94isessentialfornkcellmediatedresistancetoalethalviraldisease

Ejemplares similares