Lantana montevidensis Briq improves the aminoglycoside activity against multiresistant Escherichia coli and Staphylococcus aureus

OBJECTIVE: In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq. MATERIALS AND METHODS: The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant...

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Detalles Bibliográficos
Autores principales: Sousa, Erlanio O., Almeida, Thiago S., Rodrigues, Fabíola F.G., Campos, Adriana R., Lima, Sidney G., Costa, José G.M.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081458/
https://www.ncbi.nlm.nih.gov/pubmed/21572654
http://dx.doi.org/10.4103/0253-7613.77359
Descripción
Sumario:OBJECTIVE: In this work, we report the antibacterial and modulatory activity of Lantana montevidensis Briq. MATERIALS AND METHODS: The antibacterial activities of leaf (LELm) and root (RELm) extracts alone or in association with aminoglycosides were determined by a microdilution test. Multiresistant strains of Escherichia coli (Ec 27) and Staphylococcus aureus (Sa 358) were used. RESULTS: The results show the inhibitory activity of LELm against E. coli (minimal inhibitory concentration [MIC] 16 μg/mL) and S. aureus (MIC 128 μg/mL). The synergistic effect of the extracts and aminoglycosides was verified too. The maximum effects were obtained with RELm with gentamicin against E. coli with MIC reduction (312 to 2 μL). CONCLUSION: The data from this study are indicative of the activity antibacterial of extracts of L. montevidensis and its potential in modifying the resistance of aminoglycosides.

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