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Impact of proton pump inhibitors on efficacy of clopidogrel: Review of evidence

Clopidogrel is a prodrug which requires cytochrome P450 2C19 (CYP 2C19) enzyme for its conversion to an active thiol metabolite. Proton pump inhibitors (PPIs) inhibits enzyme CYP 2C19 interfering with the conversion of clopidogrel into its active metabolite. Studies document the possible interaction...

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Detalles Bibliográficos
Autores principales:	Mistry, Suresh D., Trivedi, Hiren R., Parmar, Dinesh M., Dalvi, Prashant S., Jiyo, Chacko
Formato:	Texto
Lenguaje:	English
Publicado:	Medknow Publications 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081459/ https://www.ncbi.nlm.nih.gov/pubmed/21572655 http://dx.doi.org/10.4103/0253-7613.77360

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