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The effect of mitoxantrone as an anticancer drug on hepatocytes nuclei and chromatin: Selective release of histone proteins

OBJECTIVES: Mitoxantrone is an anticancer drug widely used in the treatment of various cancers. In the present study the effect of mitoxantrone on chromatin proteins of intact hepatocytes nuclei was investigated and compared with soluble chromatin. MATERIALS AND METHODS: UV/Vis spectroscopy, SDS pol...

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Detalles Bibliográficos
Autores principales:	Hajihassan, Zahra, Rabbani-Chadegani, Azra
Formato:	Texto
Lenguaje:	English
Publicado:	Medknow Publications 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081460/ https://www.ncbi.nlm.nih.gov/pubmed/21572656 http://dx.doi.org/10.4103/0253-7613.77362

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