Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats

OBJECTIVE: To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats. MATERIALS AND METHODS: Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were emp...

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Detalles Bibliográficos
Autores principales: Champatisingh, D., Sahu, P.K., Pal, A., Nanda, G.S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081462/
https://www.ncbi.nlm.nih.gov/pubmed/21572658
http://dx.doi.org/10.4103/0253-7613.77368
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author Champatisingh, D.
Sahu, P.K.
Pal, A.
Nanda, G.S.
author_facet Champatisingh, D.
Sahu, P.K.
Pal, A.
Nanda, G.S.
author_sort Champatisingh, D.
collection PubMed
description OBJECTIVE: To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats. MATERIALS AND METHODS: Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed. RESULTS: M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE. CONCLUSIONS: M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity.
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spelling pubmed-30814622011-05-13 Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats Champatisingh, D. Sahu, P.K. Pal, A. Nanda, G.S. Indian J Pharmacol Research Article OBJECTIVE: To assess the anticataleptic and antiepileptic activity of leaves of Mucuna pruriens in albino rats. MATERIALS AND METHODS: Haloperidol-induced catalepsy (HIC), maximum electro-shock (MES) method, pilocarpine-induced Status epilepticus (PISE) and single-dose effect of M. pruriens were employed. RESULTS: M. pruriens (100 mg/kg) had significant anticataleptic and antiepileptic activity in HIC, MES, and PISE. CONCLUSIONS: M. pruriens extract has the potential to be an anticataleptic and antiepileptic drug. Dopamine and 5-HT may have a role in such activity. Medknow Publications 2011-04 /pmc/articles/PMC3081462/ /pubmed/21572658 http://dx.doi.org/10.4103/0253-7613.77368 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Champatisingh, D.
Sahu, P.K.
Pal, A.
Nanda, G.S.
Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
title Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
title_full Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
title_fullStr Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
title_full_unstemmed Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
title_short Anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens: A study on role of dopaminergic system in epilepsy in albino rats
title_sort anticataleptic and antiepileptic activity of ethanolic extract of leaves of mucuna pruriens: a study on role of dopaminergic system in epilepsy in albino rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081462/
https://www.ncbi.nlm.nih.gov/pubmed/21572658
http://dx.doi.org/10.4103/0253-7613.77368
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