Nevus Depigmentosus Treated by Melanocyte–Keratinocyte Transplantation

BACKGROUND: Nevus depigmentosus is a congenital, nonprogressive hypopigmented disorder. Various therapeutic methods have been attempted to repigment nevus with variable results. OBJECTIVE: The objective of this study is to report our experience of treatment of nevus depigmentosus with a combination of noncultured melanocyte–keratinocyte transplantation (MKTP) and excimer laser sessions. MATERIALS AND METHODS: Six patients (male 1, female 5) of nevus depigmentosus were treated with a combination of noncultured melanocyte–keratinocyte transplantation and excimer laser. One patient was lost to follow-up. Remaining five patients were observed for a period ranging from 7 to 30 months. RESULTS: Two patients responded poorly to MKTP. The remaining three patients responded with repigmentation ranging from 80% to 100% but the quality of repigmentation was unsatisfactory in two of them. CONCLUSION: Though repigmentation of nevus depigmentosus is possible by grafting techniques, the results are inconsistent and recurrence is possible.