The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes

[Image: see text] The natural product austocystin D was identified as a potent cytotoxic agent with in vivo antitumor activity and selectivity for cells expressing the multidrug resistance transporter MDR1. We sought to elucidate the mechanism of austocystin D’s selective cytotoxic activity. Here we...

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Detalles Bibliográficos
Autores principales: Marks, Kevin M., Park, Eun Sun, Arefolov, Alexander, Russo, Katie, Ishihara, Keiko, Ring, Jennifer E., Clardy, Jon, Clarke, Astrid S., Pelish, Henry E.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081663/
https://www.ncbi.nlm.nih.gov/pubmed/21348461
http://dx.doi.org/10.1021/np100429s

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