SirT1 brings stemness closer to cancer and aging

Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate th...

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Detalles Bibliográficos
Autores principales: Calvanese, Vincenzo, Fraga, Mario F.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082011/
https://www.ncbi.nlm.nih.gov/pubmed/21307403
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author Calvanese, Vincenzo
Fraga, Mario F.
author_facet Calvanese, Vincenzo
Fraga, Mario F.
author_sort Calvanese, Vincenzo
collection PubMed
description Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.
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spelling pubmed-30820112011-04-28 SirT1 brings stemness closer to cancer and aging Calvanese, Vincenzo Fraga, Mario F. Aging (Albany NY) Research Perspective Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy. Impact Journals LLC 2011-02-09 /pmc/articles/PMC3082011/ /pubmed/21307403 Text en Copyright: © 2011 Calvanese and Fraga http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
Calvanese, Vincenzo
Fraga, Mario F.
SirT1 brings stemness closer to cancer and aging
title SirT1 brings stemness closer to cancer and aging
title_full SirT1 brings stemness closer to cancer and aging
title_fullStr SirT1 brings stemness closer to cancer and aging
title_full_unstemmed SirT1 brings stemness closer to cancer and aging
title_short SirT1 brings stemness closer to cancer and aging
title_sort sirt1 brings stemness closer to cancer and aging
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082011/
https://www.ncbi.nlm.nih.gov/pubmed/21307403
work_keys_str_mv AT calvanesevincenzo sirt1bringsstemnessclosertocancerandaging
AT fragamariof sirt1bringsstemnessclosertocancerandaging

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