Cell cycle arrest is not senescence

DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle ar...

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Detalles Bibliográficos
Autor principal: Blagosklonny, Mikhail V.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082019/
https://www.ncbi.nlm.nih.gov/pubmed/21297220
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
collection PubMed
description DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more misleadingly, with growth inhibition. With such misconceptions, cellular senescence cannot be linked to organismal aging. Also, the relation between cancer and senescence is distorted. Here I discuss why the link between arrest and senescence is semi-coincidental and how senescence is related to aging and cancer.
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spelling pubmed-30820192011-04-28 Cell cycle arrest is not senescence Blagosklonny, Mikhail V. Aging (Albany NY) Review DNA damaging agents and radiation, cytotoxins and anti-cancer drugs, telomere erosion and cytokines, culture shock and mitogenic stimuli, oncogenes and tumor suppressors can induce both cell cycle arrest and cellular senescence. Due to this semi-coincidence, senescence is confused with cell cycle arrest, or even more misleadingly, with growth inhibition. With such misconceptions, cellular senescence cannot be linked to organismal aging. Also, the relation between cancer and senescence is distorted. Here I discuss why the link between arrest and senescence is semi-coincidental and how senescence is related to aging and cancer. Impact Journals LLC 2011-02-06 /pmc/articles/PMC3082019/ /pubmed/21297220 Text en Copyright: © 2011 Blagosklonny http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Blagosklonny, Mikhail V.
Cell cycle arrest is not senescence
title Cell cycle arrest is not senescence
title_full Cell cycle arrest is not senescence
title_fullStr Cell cycle arrest is not senescence
title_full_unstemmed Cell cycle arrest is not senescence
title_short Cell cycle arrest is not senescence
title_sort cell cycle arrest is not senescence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082019/
https://www.ncbi.nlm.nih.gov/pubmed/21297220
work_keys_str_mv AT blagosklonnymikhailv cellcyclearrestisnotsenescence

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