Putting the brakes on the unfolded protein response

The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201008071) provide insight into how the u...

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Detalles Bibliográficos
Autores principales: Sicheri, Frank, Silverman, Robert H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082173/
https://www.ncbi.nlm.nih.gov/pubmed/21444688
http://dx.doi.org/10.1083/jcb.201101105
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author Sicheri, Frank
Silverman, Robert H.
author_facet Sicheri, Frank
Silverman, Robert H.
author_sort Sicheri, Frank
collection PubMed
description The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201008071) provide insight into how the unfolded protein response is tamped down to restore normal endoplasmic reticulum function. Although both papers implicate the Ire1 kinase domain as the key effector of the off-switch mechanism, alternate models for how this is achieved are proposed.
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spelling pubmed-30821732011-10-04 Putting the brakes on the unfolded protein response Sicheri, Frank Silverman, Robert H. J Cell Biol Reviews The unfolded protein response is an ancient cellular pathway for rapidly responding to endoplasmic reticulum stress. Two studies in this issue (Rubio et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201007077 and Chawla et al. 2011. J. Cell. Biol. doi:10.1083/jcb.201008071) provide insight into how the unfolded protein response is tamped down to restore normal endoplasmic reticulum function. Although both papers implicate the Ire1 kinase domain as the key effector of the off-switch mechanism, alternate models for how this is achieved are proposed. The Rockefeller University Press 2011-04-04 /pmc/articles/PMC3082173/ /pubmed/21444688 http://dx.doi.org/10.1083/jcb.201101105 Text en © 2011 Sicheri and Silverman This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Sicheri, Frank
Silverman, Robert H.
Putting the brakes on the unfolded protein response
title Putting the brakes on the unfolded protein response
title_full Putting the brakes on the unfolded protein response
title_fullStr Putting the brakes on the unfolded protein response
title_full_unstemmed Putting the brakes on the unfolded protein response
title_short Putting the brakes on the unfolded protein response
title_sort putting the brakes on the unfolded protein response
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082173/
https://www.ncbi.nlm.nih.gov/pubmed/21444688
http://dx.doi.org/10.1083/jcb.201101105
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