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Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity

Accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). Ire1, an ER-resident transmembrane kinase/RNase, senses the protein folding status inside the ER. When activated, Ire1 oligomerizes and trans-autophosphorylates, activatin...

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Detalles Bibliográficos
Autores principales:	Rubio, Claudia, Pincus, David, Korennykh, Alexei, Schuck, Sebastian, El-Samad, Hana, Walter, Peter
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082176/ https://www.ncbi.nlm.nih.gov/pubmed/21444684 http://dx.doi.org/10.1083/jcb.201007077

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