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Clinical characteristics and risk factors of sporadic Hepatitis E in central China

BACKGROUND: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. RESULTS: Sporadic HE can occur throughout the year...

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Autores principales: Zhang, Shujun, Wang, Jingjing, Yuan, Quan, Ge, Shengxiang, Zhang, Jun, Xia, Ningshao, Tian, Deying
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082222/
https://www.ncbi.nlm.nih.gov/pubmed/21453549
http://dx.doi.org/10.1186/1743-422X-8-152
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author Zhang, Shujun
Wang, Jingjing
Yuan, Quan
Ge, Shengxiang
Zhang, Jun
Xia, Ningshao
Tian, Deying
author_facet Zhang, Shujun
Wang, Jingjing
Yuan, Quan
Ge, Shengxiang
Zhang, Jun
Xia, Ningshao
Tian, Deying
author_sort Zhang, Shujun
collection PubMed
description BACKGROUND: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. RESULTS: Sporadic HE can occur throughout the year, with the highest incidence rate in the first quarter of a year, in central of China. Of the 210 patients, 85.2% were male, and the most common clinical symptoms were jaundice (85.7%), fatigue (70.5%) and anorexia (64.8%). Total bilirubin (TBil), blood urea nitrogen (BUN), and international normalized ratio (INR) were found as major risk factors for death of HE patients. There was an overall mortality of 10%, and the mortality in the cirrhotic and non-cirrhotic group was 25% and 6.47%, respectively. Moreover, hepatitis E virus (HEV) infected patients with liver cirrhosis had a higher mortality and incidence of complications. CONCLUSIONS: TBil, BUN, and INR are major risk factors of mortality for HE. Liver cirrhosis can aggravate HE, and lead to a higher mortality. HEV infection can cause decompensation in patients with cirrhosis, as evidenced by a worsening Child-Pugh score.
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spelling pubmed-30822222011-04-27 Clinical characteristics and risk factors of sporadic Hepatitis E in central China Zhang, Shujun Wang, Jingjing Yuan, Quan Ge, Shengxiang Zhang, Jun Xia, Ningshao Tian, Deying Virol J Research BACKGROUND: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. RESULTS: Sporadic HE can occur throughout the year, with the highest incidence rate in the first quarter of a year, in central of China. Of the 210 patients, 85.2% were male, and the most common clinical symptoms were jaundice (85.7%), fatigue (70.5%) and anorexia (64.8%). Total bilirubin (TBil), blood urea nitrogen (BUN), and international normalized ratio (INR) were found as major risk factors for death of HE patients. There was an overall mortality of 10%, and the mortality in the cirrhotic and non-cirrhotic group was 25% and 6.47%, respectively. Moreover, hepatitis E virus (HEV) infected patients with liver cirrhosis had a higher mortality and incidence of complications. CONCLUSIONS: TBil, BUN, and INR are major risk factors of mortality for HE. Liver cirrhosis can aggravate HE, and lead to a higher mortality. HEV infection can cause decompensation in patients with cirrhosis, as evidenced by a worsening Child-Pugh score. BioMed Central 2011-04-01 /pmc/articles/PMC3082222/ /pubmed/21453549 http://dx.doi.org/10.1186/1743-422X-8-152 Text en Copyright ©2011 Zhang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Zhang, Shujun
Wang, Jingjing
Yuan, Quan
Ge, Shengxiang
Zhang, Jun
Xia, Ningshao
Tian, Deying
Clinical characteristics and risk factors of sporadic Hepatitis E in central China
title Clinical characteristics and risk factors of sporadic Hepatitis E in central China
title_full Clinical characteristics and risk factors of sporadic Hepatitis E in central China
title_fullStr Clinical characteristics and risk factors of sporadic Hepatitis E in central China
title_full_unstemmed Clinical characteristics and risk factors of sporadic Hepatitis E in central China
title_short Clinical characteristics and risk factors of sporadic Hepatitis E in central China
title_sort clinical characteristics and risk factors of sporadic hepatitis e in central china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082222/
https://www.ncbi.nlm.nih.gov/pubmed/21453549
http://dx.doi.org/10.1186/1743-422X-8-152
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