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Clinical characteristics and risk factors of sporadic Hepatitis E in central China
BACKGROUND: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. RESULTS: Sporadic HE can occur throughout the year...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082222/ https://www.ncbi.nlm.nih.gov/pubmed/21453549 http://dx.doi.org/10.1186/1743-422X-8-152 |
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author | Zhang, Shujun Wang, Jingjing Yuan, Quan Ge, Shengxiang Zhang, Jun Xia, Ningshao Tian, Deying |
author_facet | Zhang, Shujun Wang, Jingjing Yuan, Quan Ge, Shengxiang Zhang, Jun Xia, Ningshao Tian, Deying |
author_sort | Zhang, Shujun |
collection | PubMed |
description | BACKGROUND: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. RESULTS: Sporadic HE can occur throughout the year, with the highest incidence rate in the first quarter of a year, in central of China. Of the 210 patients, 85.2% were male, and the most common clinical symptoms were jaundice (85.7%), fatigue (70.5%) and anorexia (64.8%). Total bilirubin (TBil), blood urea nitrogen (BUN), and international normalized ratio (INR) were found as major risk factors for death of HE patients. There was an overall mortality of 10%, and the mortality in the cirrhotic and non-cirrhotic group was 25% and 6.47%, respectively. Moreover, hepatitis E virus (HEV) infected patients with liver cirrhosis had a higher mortality and incidence of complications. CONCLUSIONS: TBil, BUN, and INR are major risk factors of mortality for HE. Liver cirrhosis can aggravate HE, and lead to a higher mortality. HEV infection can cause decompensation in patients with cirrhosis, as evidenced by a worsening Child-Pugh score. |
format | Text |
id | pubmed-3082222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30822222011-04-27 Clinical characteristics and risk factors of sporadic Hepatitis E in central China Zhang, Shujun Wang, Jingjing Yuan, Quan Ge, Shengxiang Zhang, Jun Xia, Ningshao Tian, Deying Virol J Research BACKGROUND: Epidemiological investigations, detections and vaccines of hepatitis E (HE) have been paid a focus of attention in prior studies, while studies on clinical features and risk factors with a large number of sporadic HE patients are scarce. RESULTS: Sporadic HE can occur throughout the year, with the highest incidence rate in the first quarter of a year, in central of China. Of the 210 patients, 85.2% were male, and the most common clinical symptoms were jaundice (85.7%), fatigue (70.5%) and anorexia (64.8%). Total bilirubin (TBil), blood urea nitrogen (BUN), and international normalized ratio (INR) were found as major risk factors for death of HE patients. There was an overall mortality of 10%, and the mortality in the cirrhotic and non-cirrhotic group was 25% and 6.47%, respectively. Moreover, hepatitis E virus (HEV) infected patients with liver cirrhosis had a higher mortality and incidence of complications. CONCLUSIONS: TBil, BUN, and INR are major risk factors of mortality for HE. Liver cirrhosis can aggravate HE, and lead to a higher mortality. HEV infection can cause decompensation in patients with cirrhosis, as evidenced by a worsening Child-Pugh score. BioMed Central 2011-04-01 /pmc/articles/PMC3082222/ /pubmed/21453549 http://dx.doi.org/10.1186/1743-422X-8-152 Text en Copyright ©2011 Zhang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Zhang, Shujun Wang, Jingjing Yuan, Quan Ge, Shengxiang Zhang, Jun Xia, Ningshao Tian, Deying Clinical characteristics and risk factors of sporadic Hepatitis E in central China |
title | Clinical characteristics and risk factors of sporadic Hepatitis E in central China |
title_full | Clinical characteristics and risk factors of sporadic Hepatitis E in central China |
title_fullStr | Clinical characteristics and risk factors of sporadic Hepatitis E in central China |
title_full_unstemmed | Clinical characteristics and risk factors of sporadic Hepatitis E in central China |
title_short | Clinical characteristics and risk factors of sporadic Hepatitis E in central China |
title_sort | clinical characteristics and risk factors of sporadic hepatitis e in central china |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082222/ https://www.ncbi.nlm.nih.gov/pubmed/21453549 http://dx.doi.org/10.1186/1743-422X-8-152 |
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