A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB

BACKGROUND: The transcription factor STAT3 (signal transducer and activator of transcription 3) is frequently activated in tumor cells. Activated STAT3 forms homodimers, or heterodimers with other TFs such as NF-κB, which becomes activated. Cytoplasmic STAT3 dimers are activated by tyrosine phosphor...

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Detalles Bibliográficos
Autores principales: Souissi, Inès, Najjar, Imen, Ah-Koon, Laurent, Schischmanoff, Pierre Olivier, Lesage, Denis, Le Coquil, Stéphanie, Roger, Claudine, Dusanter-Fourt, Isabelle, Varin-Blank, Nadine, Cao, An, Metelev, Valeri, Baran-Marszak, Fanny, Fagard, Remi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082224/
https://www.ncbi.nlm.nih.gov/pubmed/21486470
http://dx.doi.org/10.1186/1471-2121-12-14

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