Dominant Prion Mutants Induce Curing Through Pathways That Promote Chaperone-Mediated Disaggregation

Protein misfolding underlies many neurodegenerative diseases, including the Transmissible Spongiform Encephalopathies (prion diseases). While cells typically recognize and process misfolded proteins, prion proteins evade protective measures by forming stable, self-replicating aggregates. However, co...

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Detalles Bibliográficos
Autores principales: DiSalvo, Susanne, Derdowski, Aaron, Pezza, John A., Serio, Tricia R.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082495/
https://www.ncbi.nlm.nih.gov/pubmed/21423195
http://dx.doi.org/10.1038/nsmb.2031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082495/
https://www.ncbi.nlm.nih.gov/pubmed/21423195
http://dx.doi.org/10.1038/nsmb.2031

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