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Dominant Prion Mutants Induce Curing Through Pathways That Promote Chaperone-Mediated Disaggregation
Protein misfolding underlies many neurodegenerative diseases, including the Transmissible Spongiform Encephalopathies (prion diseases). While cells typically recognize and process misfolded proteins, prion proteins evade protective measures by forming stable, self-replicating aggregates. However, co...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082495/ https://www.ncbi.nlm.nih.gov/pubmed/21423195 http://dx.doi.org/10.1038/nsmb.2031 |