Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

TDP-43 and FUS are RNA-binding proteins that form cytoplasmic inclusions in some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, mutations in TDP-43 and FUS are linked to ALS and FTLD. However, it is unknown whether TDP-43 and FUS aggregate and ca...

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Detalles Bibliográficos
Autores principales: Sun, Zhihui, Diaz, Zamia, Fang, Xiaodong, Hart, Michael P., Chesi, Alessandra, Shorter, James, Gitler, Aaron D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082519/
https://www.ncbi.nlm.nih.gov/pubmed/21541367
http://dx.doi.org/10.1371/journal.pbio.1000614

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