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Does early-onset multiple sclerosis differ from adult-onset form in Iranian people
BACKGROUND: Few studies have attempted to delineate the clinical profile of multiple Sclerosis (MS) among people of Asia. This study sought to identify the characteristics of early-onset Multiple Sclerosis (EOMS) comparison to adult-onset form (AOMS) in Isfahan, IRAN. METHODS: This prospective study...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082796/ https://www.ncbi.nlm.nih.gov/pubmed/21526065 |
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author | Ashtari, Fereshteh Shaygannejad, Vahid Farajzadegan, Ziba Amin, Ali |
author_facet | Ashtari, Fereshteh Shaygannejad, Vahid Farajzadegan, Ziba Amin, Ali |
author_sort | Ashtari, Fereshteh |
collection | PubMed |
description | BACKGROUND: Few studies have attempted to delineate the clinical profile of multiple Sclerosis (MS) among people of Asia. This study sought to identify the characteristics of early-onset Multiple Sclerosis (EOMS) comparison to adult-onset form (AOMS) in Isfahan, IRAN. METHODS: This prospective study was conducted on 104 youths with multiple sclerosis beginning before the age of 16 years and 123 patients with adult-onset multiple sclerosis. Patients were observed for a mean period of 5 years. The common presenting symptoms, MRI finding, course of disease and disability score were compared between the two groups. RESULTS: The mean onset age of disease in youths and adults were 14 ± 1.9 and 27.7 ± 8.06 years, respectively. Female/male ratio was 4.47:1 in EOMS and 3.92:1 in AOMS, this ratio was 7:1 in early childhood MS (≤ 10 year). The most common presenting symptom was optic neuritis in the EOMS group and paresthesia in AOMS. Optic neuritis was common in AOMS too, but brainstem/cerebellar signs were more common in EOMS than AOMS. Seizure occurred more frequently in EOMS than in the AOMS group (12.6% vs. 1.6%, respectively, p < 0.001). MRI showed that brainstem plaques were more prevalent in the EOMS compared with the AOMS group. CONCLUSIONS: It was concluded that early-onset MS does not significantly differ from adult form in terms of major clinical manifestation and course of disease, however Seizure is more common in EOMS, and brainstem and cerebellar symptoms as presenting symptom are more common. |
format | Text |
id | pubmed-3082796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-30827962011-04-27 Does early-onset multiple sclerosis differ from adult-onset form in Iranian people Ashtari, Fereshteh Shaygannejad, Vahid Farajzadegan, Ziba Amin, Ali J Res Med Sci Original Article BACKGROUND: Few studies have attempted to delineate the clinical profile of multiple Sclerosis (MS) among people of Asia. This study sought to identify the characteristics of early-onset Multiple Sclerosis (EOMS) comparison to adult-onset form (AOMS) in Isfahan, IRAN. METHODS: This prospective study was conducted on 104 youths with multiple sclerosis beginning before the age of 16 years and 123 patients with adult-onset multiple sclerosis. Patients were observed for a mean period of 5 years. The common presenting symptoms, MRI finding, course of disease and disability score were compared between the two groups. RESULTS: The mean onset age of disease in youths and adults were 14 ± 1.9 and 27.7 ± 8.06 years, respectively. Female/male ratio was 4.47:1 in EOMS and 3.92:1 in AOMS, this ratio was 7:1 in early childhood MS (≤ 10 year). The most common presenting symptom was optic neuritis in the EOMS group and paresthesia in AOMS. Optic neuritis was common in AOMS too, but brainstem/cerebellar signs were more common in EOMS than AOMS. Seizure occurred more frequently in EOMS than in the AOMS group (12.6% vs. 1.6%, respectively, p < 0.001). MRI showed that brainstem plaques were more prevalent in the EOMS compared with the AOMS group. CONCLUSIONS: It was concluded that early-onset MS does not significantly differ from adult form in terms of major clinical manifestation and course of disease, however Seizure is more common in EOMS, and brainstem and cerebellar symptoms as presenting symptom are more common. Medknow Publications 2010 /pmc/articles/PMC3082796/ /pubmed/21526065 Text en © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ashtari, Fereshteh Shaygannejad, Vahid Farajzadegan, Ziba Amin, Ali Does early-onset multiple sclerosis differ from adult-onset form in Iranian people |
title | Does early-onset multiple sclerosis differ from adult-onset form in Iranian people |
title_full | Does early-onset multiple sclerosis differ from adult-onset form in Iranian people |
title_fullStr | Does early-onset multiple sclerosis differ from adult-onset form in Iranian people |
title_full_unstemmed | Does early-onset multiple sclerosis differ from adult-onset form in Iranian people |
title_short | Does early-onset multiple sclerosis differ from adult-onset form in Iranian people |
title_sort | does early-onset multiple sclerosis differ from adult-onset form in iranian people |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082796/ https://www.ncbi.nlm.nih.gov/pubmed/21526065 |
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