Thalamic Synchrony and the Adaptive Gating of Information Flow to Cortex

Although it has long been posited that sensory adaptation serves to enhance information flow in sensory pathways, the neural basis remains elusive. Simultaneous single–unit recordings in the thalamus and cortex in anesthetized rats reveal that adaptation differentially influences thalamus and cortex in a manner that fundamentally changes the nature of information conveyed about vibrissae motion. Utilizing an ideal observer of cortical activity, performance in detecting vibrissa deflections degrades with adaptation, while performance in discriminating between vibrissa deflections of different velocities is enhanced, a trend not observed in thalamus. Analysis of simultaneously recorded thalamic neurons does reveal, however, an analogous adaptive change in thalamic synchrony that mirrors the cortical response. An integrate–and–fire model using experimentally measured thalamic input reproduces the observed transformations. The results here suggest a shift in coding strategy with adaptation that directly controls information relayed to cortex, which could have implications for encoding velocity signatures of textures.