A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase β

DNA repair is required to maintain genome stability in stem cells and early embryos. At critical junctures, oxidative damage to DNA requires the base excision repair (BER) pathway. Since early zebrafish embryos lack the major polymerase in BER, DNA polymerase ß, repair proceeds via replicative polym...

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Detalles Bibliográficos
Autores principales: Pei, De-Sheng, Yang, Xiao-Jie, Liu, Wei, Guikema, Jeroen E. J., Schrader, Carol E., Strauss, Phyllis R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082881/
https://www.ncbi.nlm.nih.gov/pubmed/21172930
http://dx.doi.org/10.1093/nar/gkq1142

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