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ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism

Most type IB topoisomerases do not require ATP and Mg(2+) for activity. However, as shown previously for vaccinia topoisomerase I, we demonstrate that ATP stimulates the relaxation activity of the unusual heterodimeric type IB topoisomerase from Leishmania donovani (LdTOP1L/S) in the absence of Mg(2...

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Detalles Bibliográficos
Autores principales:	Sengupta, Souvik, Ganguly, Agneyo, Roy, Amit, BoseDasgupta, Somdeb, D’Annessa, Ilda, Desideri, Alessandro, Majumder, Hemanta K.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082896/ https://www.ncbi.nlm.nih.gov/pubmed/21186185 http://dx.doi.org/10.1093/nar/gkq1284

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