c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion of the MYC target gene upstream binding factor...

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Detalles Bibliográficos
Autores principales: Poortinga, Gretchen, Wall, Meaghan, Sanij, Elaine, Siwicki, Kasia, Ellul, Jason, Brown, Daniel, Holloway, Timothy P., Hannan, Ross D., McArthur, Grant A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082905/
https://www.ncbi.nlm.nih.gov/pubmed/21177653
http://dx.doi.org/10.1093/nar/gkq1205

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