Tg2576 Cortical Neurons That Express Human Ab Are Susceptible to Extracellular Aβ-Induced, K(+) Efflux Dependent Neurodegeneration

BACKGROUND: One of the key pathological features of AD is the formation of insoluble amyloid plaques. The major constituent of these extracellular plaques is the beta-amyloid peptide (Aβ), although Aβ is also found to accumulate intraneuronally in AD. Due to the slowly progressive nature of the dise...

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Detalles Bibliográficos
Autores principales: Ray, Shannon, Howells, Claire, Eaton, Emma D., Butler, Chris W., Shabala, Lana, Adlard, Paul A., West, Adrian K., Bennett, William R., Guillemin, Gilles J., Chung, Roger S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083396/
https://www.ncbi.nlm.nih.gov/pubmed/21556141
http://dx.doi.org/10.1371/journal.pone.0019026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083396/
https://www.ncbi.nlm.nih.gov/pubmed/21556141
http://dx.doi.org/10.1371/journal.pone.0019026

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