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A new subtype of progenitor cell in the mouse embryonic neocortex
A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083489/ https://www.ncbi.nlm.nih.gov/pubmed/21478886 http://dx.doi.org/10.1038/nn.2807 |
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author | Wang, Xiaoqun Tsai, Jin-Wu LaMonica, Bridget Kriegstein, Arnold R. |
author_facet | Wang, Xiaoqun Tsai, Jin-Wu LaMonica, Bridget Kriegstein, Arnold R. |
author_sort | Wang, Xiaoqun |
collection | PubMed |
description | A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase preceeds nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion. |
format | Text |
id | pubmed-3083489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
record_format | MEDLINE/PubMed |
spelling | pubmed-30834892011-11-01 A new subtype of progenitor cell in the mouse embryonic neocortex Wang, Xiaoqun Tsai, Jin-Wu LaMonica, Bridget Kriegstein, Arnold R. Nat Neurosci Article A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase preceeds nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion. 2011-04-10 2011-05 /pmc/articles/PMC3083489/ /pubmed/21478886 http://dx.doi.org/10.1038/nn.2807 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Wang, Xiaoqun Tsai, Jin-Wu LaMonica, Bridget Kriegstein, Arnold R. A new subtype of progenitor cell in the mouse embryonic neocortex |
title | A new subtype of progenitor cell in the mouse embryonic neocortex |
title_full | A new subtype of progenitor cell in the mouse embryonic neocortex |
title_fullStr | A new subtype of progenitor cell in the mouse embryonic neocortex |
title_full_unstemmed | A new subtype of progenitor cell in the mouse embryonic neocortex |
title_short | A new subtype of progenitor cell in the mouse embryonic neocortex |
title_sort | new subtype of progenitor cell in the mouse embryonic neocortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083489/ https://www.ncbi.nlm.nih.gov/pubmed/21478886 http://dx.doi.org/10.1038/nn.2807 |
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