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A new subtype of progenitor cell in the mouse embryonic neocortex

A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor...

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Autores principales: Wang, Xiaoqun, Tsai, Jin-Wu, LaMonica, Bridget, Kriegstein, Arnold R.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083489/
https://www.ncbi.nlm.nih.gov/pubmed/21478886
http://dx.doi.org/10.1038/nn.2807
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author Wang, Xiaoqun
Tsai, Jin-Wu
LaMonica, Bridget
Kriegstein, Arnold R.
author_facet Wang, Xiaoqun
Tsai, Jin-Wu
LaMonica, Bridget
Kriegstein, Arnold R.
author_sort Wang, Xiaoqun
collection PubMed
description A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase preceeds nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion.
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spelling pubmed-30834892011-11-01 A new subtype of progenitor cell in the mouse embryonic neocortex Wang, Xiaoqun Tsai, Jin-Wu LaMonica, Bridget Kriegstein, Arnold R. Nat Neurosci Article A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase preceeds nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion. 2011-04-10 2011-05 /pmc/articles/PMC3083489/ /pubmed/21478886 http://dx.doi.org/10.1038/nn.2807 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Wang, Xiaoqun
Tsai, Jin-Wu
LaMonica, Bridget
Kriegstein, Arnold R.
A new subtype of progenitor cell in the mouse embryonic neocortex
title A new subtype of progenitor cell in the mouse embryonic neocortex
title_full A new subtype of progenitor cell in the mouse embryonic neocortex
title_fullStr A new subtype of progenitor cell in the mouse embryonic neocortex
title_full_unstemmed A new subtype of progenitor cell in the mouse embryonic neocortex
title_short A new subtype of progenitor cell in the mouse embryonic neocortex
title_sort new subtype of progenitor cell in the mouse embryonic neocortex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083489/
https://www.ncbi.nlm.nih.gov/pubmed/21478886
http://dx.doi.org/10.1038/nn.2807
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