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Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory
Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magn...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083493/ https://www.ncbi.nlm.nih.gov/pubmed/21441920 http://dx.doi.org/10.1038/nn.2773 |
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author | Zanto, Theodore P. Rubens, Michael T. Thangavel, Arul Gazzaley, Adam |
author_facet | Zanto, Theodore P. Rubens, Michael T. Thangavel, Arul Gazzaley, Adam |
author_sort | Zanto, Theodore P. |
collection | PubMed |
description | Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imaging to guide repetitive transcranial magnetic stimulation with electroencephalographic recordings in humans, we perturbed PFC function at the inferior frontal junction prior to participants performing a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. Data further suggested that broad alpha band (7–14 Hz) phase coherence subserved this long distance top-down modulation. The results establish top-down modulation mediated by the prefrontal cortex as a causal link between early attentional processes and subsequent memory performance. |
format | Text |
id | pubmed-3083493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
record_format | MEDLINE/PubMed |
spelling | pubmed-30834932011-11-01 Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory Zanto, Theodore P. Rubens, Michael T. Thangavel, Arul Gazzaley, Adam Nat Neurosci Article Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imaging to guide repetitive transcranial magnetic stimulation with electroencephalographic recordings in humans, we perturbed PFC function at the inferior frontal junction prior to participants performing a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. Data further suggested that broad alpha band (7–14 Hz) phase coherence subserved this long distance top-down modulation. The results establish top-down modulation mediated by the prefrontal cortex as a causal link between early attentional processes and subsequent memory performance. 2011-03-27 2011-05 /pmc/articles/PMC3083493/ /pubmed/21441920 http://dx.doi.org/10.1038/nn.2773 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Zanto, Theodore P. Rubens, Michael T. Thangavel, Arul Gazzaley, Adam Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
title | Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
title_full | Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
title_fullStr | Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
title_full_unstemmed | Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
title_short | Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
title_sort | causal role of the prefrontal cortex in top-down modulation of visual processing and working memory |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083493/ https://www.ncbi.nlm.nih.gov/pubmed/21441920 http://dx.doi.org/10.1038/nn.2773 |
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