Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications

Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, Karina T, Masri, Wagih El, Osman, Aheed, Chowdhury, Joy, Johnson, William E B
Formato: Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
Materias:
Concise Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083520/
https://www.ncbi.nlm.nih.gov/pubmed/21732476
http://dx.doi.org/10.1002/stem.570
_version_ 1782202410728423424
author Wright, Karina T
Masri, Wagih El
Osman, Aheed
Chowdhury, Joy
Johnson, William E B
author_facet Wright, Karina T
Masri, Wagih El
Osman, Aheed
Chowdhury, Joy
Johnson, William E B
author_sort Wright, Karina T
collection PubMed
description Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into central nervous system cells but focus on the neurotrophic, tissue sparing, and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date. Stem Cells 2011;29:169–178
format Text
id pubmed-3083520
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Wiley Subscription Services, Inc., A Wiley Company
record_format MEDLINE/PubMed
spelling pubmed-30835202011-05-05 Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications Wright, Karina T Masri, Wagih El Osman, Aheed Chowdhury, Joy Johnson, William E B Stem Cells Concise Reviews Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigated. The objective of this review is to discuss these mechanisms; we briefly consider the controversial topic of HSC and MSC transdifferentiation into central nervous system cells but focus on the neurotrophic, tissue sparing, and reparative action of MSC grafts in the context of the spinal cord injury (SCI) milieu. We then discuss some of the specific issues related to the translation of HSC and MSC therapies for patients with SCI and present a comprehensive critique of the current bone marrow cell clinical trials for the treatment of SCI to date. Stem Cells 2011;29:169–178 Wiley Subscription Services, Inc., A Wiley Company 2011-02 2010-11-23 /pmc/articles/PMC3083520/ /pubmed/21732476 http://dx.doi.org/10.1002/stem.570 Text en Copyright © 2011 AlphaMed Press http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Concise Reviews
Wright, Karina T
Masri, Wagih El
Osman, Aheed
Chowdhury, Joy
Johnson, William E B
Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications
title Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications
title_full Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications
title_fullStr Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications
title_full_unstemmed Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications
title_short Concise Review: Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Applications
title_sort concise review: bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications
topic Concise Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083520/
https://www.ncbi.nlm.nih.gov/pubmed/21732476
http://dx.doi.org/10.1002/stem.570
work_keys_str_mv AT wrightkarinat concisereviewbonemarrowforthetreatmentofspinalcordinjurymechanismsandclinicalapplications
AT masriwagihel concisereviewbonemarrowforthetreatmentofspinalcordinjurymechanismsandclinicalapplications
AT osmanaheed concisereviewbonemarrowforthetreatmentofspinalcordinjurymechanismsandclinicalapplications
AT chowdhuryjoy concisereviewbonemarrowforthetreatmentofspinalcordinjurymechanismsandclinicalapplications
AT johnsonwilliameb concisereviewbonemarrowforthetreatmentofspinalcordinjurymechanismsandclinicalapplications

Ejemplares similares