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Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations

In a French national cohort of unaffected females carriers/non-carriers of a BRCA1/2 mutation, long-term preventive strategies and breast/ovarian cancer risk perceptions were followed up to 5 years after test result disclosure, using self-administered questionnaires. Response rate was 74%. Carriers...

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Autores principales: Julian-Reynier, Claire, Mancini, Julien, Mouret-Fourme, Emmanuelle, Gauthier-Villars, Marion, Bonadona, Valérie, Berthet, Pascaline, Fricker, Jean-Pierre, Caron, Olivier, Luporsi, Elisabeth, Noguès, Catherine
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083622/
https://www.ncbi.nlm.nih.gov/pubmed/21267012
http://dx.doi.org/10.1038/ejhg.2010.241
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author Julian-Reynier, Claire
Mancini, Julien
Mouret-Fourme, Emmanuelle
Gauthier-Villars, Marion
Bonadona, Valérie
Berthet, Pascaline
Fricker, Jean-Pierre
Caron, Olivier
Luporsi, Elisabeth
Noguès, Catherine
author_facet Julian-Reynier, Claire
Mancini, Julien
Mouret-Fourme, Emmanuelle
Gauthier-Villars, Marion
Bonadona, Valérie
Berthet, Pascaline
Fricker, Jean-Pierre
Caron, Olivier
Luporsi, Elisabeth
Noguès, Catherine
author_sort Julian-Reynier, Claire
collection PubMed
description In a French national cohort of unaffected females carriers/non-carriers of a BRCA1/2 mutation, long-term preventive strategies and breast/ovarian cancer risk perceptions were followed up to 5 years after test result disclosure, using self-administered questionnaires. Response rate was 74%. Carriers (N=101) were younger (average age±SD=37±10) than non-carriers (N=145; 42±12). There were four management strategies that comprised 88% of the decisions made by the unaffected carriers: 50% opted for breast surveillance alone, based on either magnetic resonance imaging (MRI) and other imaging (31%) or mammography alone (19%); 38% opted for either risk reducing salpingo-oophorectomy (RRSO) and breast surveillance, based on MRI and other imaging (28%) or mammography alone (10%). The other three strategies were: risk reducing mastectomy (RRM) and RRSO (5%), RRM alone (2%) and neither RRM/RRSO nor surveillance (6%). The results obtained for various age groups are presented here. Non-carriers often opted for screening despite their low cancer risk. Result disclosure increased carriers' short-term high breast/ovarian cancer risk perceptions (P⩽0.02) and decreased non-carriers' short- and long-term perceptions (P<0.001). During follow-up, high breast cancer risk perceptions increased with time among those who had no RRM and decreased in the opposite case; high ovarian cancer risk perceptions increased further with time among those who had no RRSO and decreased in the opposite case; RRSO did not affect breast cancer risk perceptions. Informed decision-making involves letting women know whether opting for RRSO and breast MRI surveillance is as effective in terms of survival as RRM and RRSO.
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spelling pubmed-30836222011-06-23 Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations Julian-Reynier, Claire Mancini, Julien Mouret-Fourme, Emmanuelle Gauthier-Villars, Marion Bonadona, Valérie Berthet, Pascaline Fricker, Jean-Pierre Caron, Olivier Luporsi, Elisabeth Noguès, Catherine Eur J Hum Genet Article In a French national cohort of unaffected females carriers/non-carriers of a BRCA1/2 mutation, long-term preventive strategies and breast/ovarian cancer risk perceptions were followed up to 5 years after test result disclosure, using self-administered questionnaires. Response rate was 74%. Carriers (N=101) were younger (average age±SD=37±10) than non-carriers (N=145; 42±12). There were four management strategies that comprised 88% of the decisions made by the unaffected carriers: 50% opted for breast surveillance alone, based on either magnetic resonance imaging (MRI) and other imaging (31%) or mammography alone (19%); 38% opted for either risk reducing salpingo-oophorectomy (RRSO) and breast surveillance, based on MRI and other imaging (28%) or mammography alone (10%). The other three strategies were: risk reducing mastectomy (RRM) and RRSO (5%), RRM alone (2%) and neither RRM/RRSO nor surveillance (6%). The results obtained for various age groups are presented here. Non-carriers often opted for screening despite their low cancer risk. Result disclosure increased carriers' short-term high breast/ovarian cancer risk perceptions (P⩽0.02) and decreased non-carriers' short- and long-term perceptions (P<0.001). During follow-up, high breast cancer risk perceptions increased with time among those who had no RRM and decreased in the opposite case; high ovarian cancer risk perceptions increased further with time among those who had no RRSO and decreased in the opposite case; RRSO did not affect breast cancer risk perceptions. Informed decision-making involves letting women know whether opting for RRSO and breast MRI surveillance is as effective in terms of survival as RRM and RRSO. Nature Publishing Group 2011-05 2011-01-26 /pmc/articles/PMC3083622/ /pubmed/21267012 http://dx.doi.org/10.1038/ejhg.2010.241 Text en Copyright © 2011 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Julian-Reynier, Claire
Mancini, Julien
Mouret-Fourme, Emmanuelle
Gauthier-Villars, Marion
Bonadona, Valérie
Berthet, Pascaline
Fricker, Jean-Pierre
Caron, Olivier
Luporsi, Elisabeth
Noguès, Catherine
Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
title Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
title_full Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
title_fullStr Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
title_full_unstemmed Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
title_short Cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for BRCA1/2 mutations
title_sort cancer risk management strategies and perceptions of unaffected women 5 years after predictive genetic testing for brca1/2 mutations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083622/
https://www.ncbi.nlm.nih.gov/pubmed/21267012
http://dx.doi.org/10.1038/ejhg.2010.241
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