Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats

In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and huma...

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Autores principales: Tarman, Kustiariyah, Lindequist, Ulrike, Wende, Kristian, Porzel, Andrea, Arnold, Norbert, Wessjohann, Ludger A.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083651/
https://www.ncbi.nlm.nih.gov/pubmed/21556160
http://dx.doi.org/10.3390/md9030294
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author Tarman, Kustiariyah
Lindequist, Ulrike
Wende, Kristian
Porzel, Andrea
Arnold, Norbert
Wessjohann, Ludger A.
author_facet Tarman, Kustiariyah
Lindequist, Ulrike
Wende, Kristian
Porzel, Andrea
Arnold, Norbert
Wessjohann, Ludger A.
author_sort Tarman, Kustiariyah
collection PubMed
description In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC(50) value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
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spelling pubmed-30836512011-05-09 Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats Tarman, Kustiariyah Lindequist, Ulrike Wende, Kristian Porzel, Andrea Arnold, Norbert Wessjohann, Ludger A. Mar Drugs Article In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC(50) value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product. Molecular Diversity Preservation International 2011-02-25 /pmc/articles/PMC3083651/ /pubmed/21556160 http://dx.doi.org/10.3390/md9030294 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tarman, Kustiariyah
Lindequist, Ulrike
Wende, Kristian
Porzel, Andrea
Arnold, Norbert
Wessjohann, Ludger A.
Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
title Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
title_full Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
title_fullStr Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
title_full_unstemmed Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
title_short Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
title_sort isolation of a new natural product and cytotoxic and antimicrobial activities of extracts from fungi of indonesian marine habitats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083651/
https://www.ncbi.nlm.nih.gov/pubmed/21556160
http://dx.doi.org/10.3390/md9030294
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