Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites

Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural p...

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Autores principales: Berrue, Fabrice, Withers, Sydnor T., Haltli, Brad, Withers, Jo, Kerr, Russell G.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083657/
https://www.ncbi.nlm.nih.gov/pubmed/21556166
http://dx.doi.org/10.3390/md9030369
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author Berrue, Fabrice
Withers, Sydnor T.
Haltli, Brad
Withers, Jo
Kerr, Russell G.
author_facet Berrue, Fabrice
Withers, Sydnor T.
Haltli, Brad
Withers, Jo
Kerr, Russell G.
author_sort Berrue, Fabrice
collection PubMed
description Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites.
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spelling pubmed-30836572011-05-09 Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites Berrue, Fabrice Withers, Sydnor T. Haltli, Brad Withers, Jo Kerr, Russell G. Mar Drugs Article Marine invertebrates have proven to be a rich source of secondary metabolites. The growing recognition that marine microorganisms associated with invertebrate hosts are involved in the biosynthesis of secondary metabolites offers new alternatives for the discovery and development of marine natural products. However, the discovery of microorganisms producing secondary metabolites previously attributed to an invertebrate host poses a significant challenge. This study describes an efficient chemical screening method utilizing a 96-well plate-based bacterial cultivation strategy to identify and isolate microbial producers of marine invertebrate-associated metabolites. Molecular Diversity Preservation International 2011-03-21 /pmc/articles/PMC3083657/ /pubmed/21556166 http://dx.doi.org/10.3390/md9030369 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Berrue, Fabrice
Withers, Sydnor T.
Haltli, Brad
Withers, Jo
Kerr, Russell G.
Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
title Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
title_full Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
title_fullStr Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
title_full_unstemmed Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
title_short Chemical Screening Method for the Rapid Identification of Microbial Sources of Marine Invertebrate-Associated Metabolites
title_sort chemical screening method for the rapid identification of microbial sources of marine invertebrate-associated metabolites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083657/
https://www.ncbi.nlm.nih.gov/pubmed/21556166
http://dx.doi.org/10.3390/md9030369
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