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Control of Advanced Cancer: The Road to Chronicity

Despite the recent trend toward a slight decrease in age-adjusted cancer mortality in some countries, crude mortality rates will continue to increase, driven by the demographic shift towards an aged population. Small molecules (small molecules and biologics) are not only a new therapeutic acquisitio...

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Detalles Bibliográficos
Autores principales: Lage, Agustin, Crombet, Tania
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083664/
https://www.ncbi.nlm.nih.gov/pubmed/21556173
http://dx.doi.org/10.3390/ijerph8030683
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author Lage, Agustin
Crombet, Tania
author_facet Lage, Agustin
Crombet, Tania
author_sort Lage, Agustin
collection PubMed
description Despite the recent trend toward a slight decrease in age-adjusted cancer mortality in some countries, crude mortality rates will continue to increase, driven by the demographic shift towards an aged population. Small molecules (small molecules and biologics) are not only a new therapeutic acquisition, but the tools of a more fundamental transition: the transformation of cancer from a rapidly fatal disease into a chronic condition. Antibodies and cancer vaccines can be used for a long time, even beyond progressive disease, and in aged patients, usually unfit for more aggressive conventional treatments. However, this transition to chronicity will require novel developmental guidelines adequate to this kind of drugs, for which optimal dose is not usually the maximal tolerated dose, pharmacokinetics does not define treatment schedule, and tumor shrinkage is not a good correlate of survival. The ongoing cancer immunotherapy program (including several monoclonal antibodies and therapeutic vaccines) at the Centre of Molecular Immunology can illustrate the issues to be addressed, both biological and social, along the path to transform advanced cancer into a chronic non-communicable disease compatible with years of quality life.
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spelling pubmed-30836642011-05-09 Control of Advanced Cancer: The Road to Chronicity Lage, Agustin Crombet, Tania Int J Environ Res Public Health Review Despite the recent trend toward a slight decrease in age-adjusted cancer mortality in some countries, crude mortality rates will continue to increase, driven by the demographic shift towards an aged population. Small molecules (small molecules and biologics) are not only a new therapeutic acquisition, but the tools of a more fundamental transition: the transformation of cancer from a rapidly fatal disease into a chronic condition. Antibodies and cancer vaccines can be used for a long time, even beyond progressive disease, and in aged patients, usually unfit for more aggressive conventional treatments. However, this transition to chronicity will require novel developmental guidelines adequate to this kind of drugs, for which optimal dose is not usually the maximal tolerated dose, pharmacokinetics does not define treatment schedule, and tumor shrinkage is not a good correlate of survival. The ongoing cancer immunotherapy program (including several monoclonal antibodies and therapeutic vaccines) at the Centre of Molecular Immunology can illustrate the issues to be addressed, both biological and social, along the path to transform advanced cancer into a chronic non-communicable disease compatible with years of quality life. Molecular Diversity Preservation International (MDPI) 2011-03 2011-03-01 /pmc/articles/PMC3083664/ /pubmed/21556173 http://dx.doi.org/10.3390/ijerph8030683 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Lage, Agustin
Crombet, Tania
Control of Advanced Cancer: The Road to Chronicity
title Control of Advanced Cancer: The Road to Chronicity
title_full Control of Advanced Cancer: The Road to Chronicity
title_fullStr Control of Advanced Cancer: The Road to Chronicity
title_full_unstemmed Control of Advanced Cancer: The Road to Chronicity
title_short Control of Advanced Cancer: The Road to Chronicity
title_sort control of advanced cancer: the road to chronicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083664/
https://www.ncbi.nlm.nih.gov/pubmed/21556173
http://dx.doi.org/10.3390/ijerph8030683
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