Effects of Intermediates between Vitamins K(2) and K(3) on Mammalian DNA Polymerase Inhibition and Anti-Inflammatory Activity

Previously, we reported that vitamin K(3) (VK(3)), but not VK(1) or VK(2) (=MK-4), inhibits the activity of human DNA polymerase γ (pol γ). In this study, we chemically synthesized three intermediate compounds between VK(2) and VK(3), namely MK-3, MK-2 and MK-1, and investigated the inhibitory effec...

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Detalles Bibliográficos
Autores principales: Mizushina, Yoshiyuki, Maeda, Jun, Irino, Yasuhiro, Nishida, Masayuki, Nishiumi, Shin, Kondo, Yasuyuki, Nishio, Kazuyuki, Kuramochi, Kouji, Tsubaki, Kazunori, Kuriyama, Isoko, Azuma, Takeshi, Yoshida, Hiromi, Yoshida, Masaru
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083694/
https://www.ncbi.nlm.nih.gov/pubmed/21541047
http://dx.doi.org/10.3390/ijms12021115

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